GtoPdb Ligand ID: 7748

Synonyms: LA480 | LY-2875358 | LY2875358
Compound class: Antibody
Comment: Emibetuzumab is an investigatonal monoclonal antibody designed as a potential treatment for advanced or metastatic solid tumors.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record.
Bioactivity Comments
Peptide sequence alignment suggests that emibetuzumab is antibody C8-H241 in patent US8217148 [1]. The binding data mapped to this antibody is derived from this patent.
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
MET proto-oncogene, receptor tyrosine kinase Hs Antibody Binding >10.0 pKd - 1
pKd >10.0 (Kd <1x10-10 M) [1]
Description: binding constant for hMET extracellular domain measured using proprietary BIACore® technology