Synonyms: AZ 4800 | AZ-4800
Compound class:
Synthetic organic
Comment: AZD4800 is one of several AstraZeneca gamma secretase modulators [1]. It has recently been used for targeting amyloid β production in a mouse model of Alzheimer's disease (AD) in combination with the BACE1 inhibitor AZ3971 [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
The effect of AZ4800 on Aβ peptide generation has been measured in HEK/APPswe cells. AZ4800 (and AZ3303 and AZ1136) reduced Aβ40 as well as Aβ42 but appeared 2–15-fold more potent in reducing Aβ42 levels. |
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