apelin receptor early endogenous ligand   Click here for help

GtoPdb Ligand ID: 7930

Abbreviated name: ELA
Synonyms: ELABELA | Ende | tdl | toddler
Comment: ELA signals via the apelin receptor to mediate endoderm differentiation and embryonic heart morphogenesis, and is present prior to the expression of apelin, making this the earliest ligand recognised by the apelin receptor [1]. More recently (Apr 2017) the activity as an endogenous agonist of the Apelin APJ receptor in the adult cardiovascular system was demonstracted [3].
Species: Human
Click here for help
Bioactivity Comments
Alkaline phosphatase-conjugated APELA has been demonstrated to bind to the human apelin receptor by in vitro colourimetric assay [1].
Natural/Endogenous Targets
apelin receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
apelin receptor Primary target of this compound Ligand is endogenous in the given species Hs Agonist Agonist 9.3 pKd - 2
pKd 9.3 (Kd 5.1x10-10 M) [2]