apelin receptor early endogenous ligand   Click here for help

GtoPdb Ligand ID: 7930

Abbreviated name: ELA
Synonyms: ELABELA | Ende | tdl | toddler
Comment: ELA signals via the apelin receptor to mediate endoderm differentiation and embryonic heart morphogenesis, and is present prior to the expression of apelin, making this the earliest ligand recognised by the apelin receptor [1]. More recently (Apr 2017) the activity as an endogenous agonist of the Apelin APJ receptor in the adult cardiovascular system was demonstracted [3].
Species: Human
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1. Chng SC, Ho L, Tian J, Reversade B. (2013)
ELABELA: a hormone essential for heart development signals via the apelin receptor.
Dev Cell, 27 (6): 672-80. [PMID:24316148]
2. Deng C, Chen H, Yang N, Feng Y, Hsueh AJ. (2015)
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling.
J Biol Chem, 290 (30): 18261-8. [PMID:25995451]
3. Yang P, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA et al.. (2017)
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.
Circulation, 135 (12): 1160-1173. [PMID:28137936]