CP-673451   Click here for help

GtoPdb Ligand ID: 8069

Synonyms: CP-673,451
PDB Ligand
Compound class: Synthetic organic
Comment: CP-673451 is an investigational, selective inhibitor of PDGFRα and PDGFRβ [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 77.91
Molecular weight 417.22
XLogP 3.84
No. Lipinski's rules broken 0
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Canonical SMILES COCCOc1ccc2c(c1)ncn2c1ccc2c(n1)c(ccc2)N1CCC(CC1)N
Isomeric SMILES COCCOc1ccc2c(c1)ncn2c1ccc2c(n1)c(ccc2)N1CCC(CC1)N
InChI InChI=1S/C24H27N5O2/c1-30-13-14-31-19-6-7-21-20(15-19)26-16-29(21)23-8-5-17-3-2-4-22(24(17)27-23)28-11-9-18(25)10-12-28/h2-8,15-16,18H,9-14,25H2,1H3
Bioactivity Comments
CP-673451 has antiangiogenic and antitumour activity in vivo [1]. Inhibitory activity at PDGFRα is 10-fold less than for PDGFRβ [1]. The related receptor tyrosine kinase c-Kit is an off-target of this compound.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
platelet derived growth factor receptor beta Primary target of this compound Hs Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 1x10-9 M) [1]
platelet derived growth factor receptor alpha Primary target of this compound Hs Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
KIT proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 6.6 pIC50 - 1
pIC50 6.6 (IC50 2.52x10-7 M) [1]