CCL20   Click here for help

GtoPdb Ligand ID: 808

Synonyms: LARC | liver and activation-regulated chemokine | macrophage inflammatory protein-3α | MIP-3α
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL20 is a CC family chemokine. It is the only identified ligand for the chemokine receptor CCR6.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
CCR6
CXCR3
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCR3 Ligand is endogenous in the given species Hs Agonist Full agonist 6.8 pKi - 9
⤷ pKi 6.8 [9]
CCR6 Ligand is endogenous in the given species Hs Agonist Full agonist 7.9 – 8.5 pIC50 - 1,3,8
⤷ pIC50 7.9 – 8.5 [1,3,8]
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
GSK3050002 Peptide Primary target of this compound Hs Antibody Binding 10.3 pKd - 4
⤷ pKd 10.3 (Kd 4.8x10-11 M) [4]
Description: Binding to human CCL20.