epratuzumab   Click here for help

GtoPdb Ligand ID: 8088

Synonyms: 90Y-DOTA-hLL2 | 90Y-epratuzumab tetraxetan | 90Y-hLL2 | AMG-412 | IMMU-hLL2 | LymphoCide® (proposed proprietary name)
Immunopharmacology Ligand
Compound class: Antibody
Comment: Epratuzumab is a humanized monoclonal antibody. It is derived from the murine IG2a monoclonal antibody, LL2 (EPB-2). Epratuzumab has antineoplastic and antiinflammatory actions [1].
The antibody can be conjugated with tetraxetan (DOTA) which allows chelation of radionucleotides such as yttrium-90 [5].
Bioactivity Comments
We have been unable to find a publicly available binding affinity for interaction between epratuzumab and CD22. However, this interaction as the primary mmoa is supported in the published literature [7,9].