epratuzumab

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epratuzumab

GtoPdb Ligand ID: 8088

Compound class: Antibody

Comment: Epratuzumab is a humanized monoclonal antibody. It is derived from the murine IG2a monoclonal antibody, LL2 (EPB-2). Epratuzumab has antineoplastic and antiinflammatory actions [1].
The antibody can be conjugated with tetraxetan (DOTA) which allows chelation of radionucleotides such as yttrium-90 [5].

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Epratuzumab was investigated for antiinflammatory actions in SLE, but was found not to be effective following Phase 3 trial evaluation [3,6].

Immunopharmacology Comments

Epratuzumab was investigated for antiinflammatory actions in SLE, but was found not to be effective following Phase 3 trial evaluation [3,6].

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Systemic lupus erythematosus	Disease Ontology: DOID:9074 OMIM: 152700 Orphanet: ORPHA536	Epratuzumab is being investigated for antiinflammatory actions in SLE.