CXCL1   Click here for help

GtoPdb Ligand ID: 819

Synonyms: GROα | melanocyte growth-stimulatory activity | MIP-2
Immunopharmacology Ligand
Comment: CXCL1 is a C-X-C motif chemokine expressed by macrophages, neutrophils and epithelial cells, that acts via the chemokine receptor CXCR2. CXCL1 is expressed by keratinocytes and endothelial cells at sites of epithelialization and neovascularization in the process of wound healing [2].
Species: Human
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Natural/Endogenous Targets
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCR2 Ligand is endogenous in the given species Hs Agonist Full agonist 8.4 – 9.7 pKi - 3-5
pKi 8.4 – 9.7 [3-5]
CXCR2 Mm Agonist Full agonist 8.1 pKi - 1
pKi 8.1 [1]