CXCL1   Click here for help

GtoPdb Ligand ID: 819

Synonyms: GROα | melanocyte growth-stimulatory activity | MIP-2
Immunopharmacology Ligand
Comment: CXCL1 is a C-X-C motif chemokine expressed by macrophages, neutrophils and epithelial cells, that acts via the chemokine receptor CXCR2. CXCL1 is expressed by keratinocytes and endothelial cells at sites of epithelialization and neovascularization in the process of wound healing [2].
Species: Human
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1. Bozic CR, Gerard NP, von Uexkull-Guldenband C, Kolakowski Jr LF, Conklyn MJ, Breslow R, Showell HJ, Gerard C. (1994)
The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.
J Biol Chem, 269 (47): 29355-8. [PMID:7961909]
2. Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, Richmond A. (2000)
Delayed wound healing in CXCR2 knockout mice.
J Invest Dermatol, 115 (2): 234-44. [PMID:10951241]
3. Hall DA, Beresford IJ, Browning C, Giles H. (1999)
Signalling by CXC-chemokine receptors 1 and 2 expressed in CHO cells: a comparison of calcium mobilization, inhibition of adenylyl cyclase and stimulation of GTPgammaS binding induced by IL-8 and GROalpha.
Br J Pharmacol, 126 (3): 810-8. [PMID:10188995]
4. Lee J, Horuk R, Rice GC, Bennett GL, Camerato T, Wood WI. (1992)
Characterization of two high affinity human interleukin-8 receptors.
J Biol Chem, 267 (23): 16283-7. [PMID:1379593]
5. Wu L, Ruffing N, Shi X, Newman W, Soler D, Mackay CR, Qin S. (1996)
Discrete steps in binding and signaling of interleukin-8 with its receptor.
J Biol Chem, 271 (49): 31202-9. [PMID:8940121]