abaloparatide   Click here for help

GtoPdb Ligand ID: 8299

Synonyms: BA058 | Tymlos®
Approved drug
abaloparatide is an approved drug (FDA (2017))
Comment: Abaloparatide is a synthetic analogue of the 34 amino-terminal residues of human parathyroid hormone-related protein (PTHrP) [1]. Compare this to the approved drug teriparatide which is a synthetic analogue of human parathyroid hormone (PTH). Abaloparatide and teriparatide are synthetic peptides that help grow and strengthen bone.
Bioactivity Comments
As this is an analogue of an endogenous peptide we have tagged its primary target as the PTH1 receptor, although we have been unable to find affinity data for the peptide-receptor interaction.
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
PTH1 receptor Primary target of this compound Hs Agonist Agonist - - - 1