abaloparatide   Click here for help

GtoPdb Ligand ID: 8299

Synonyms: BA058 | Tymlos®
Approved drug
abaloparatide is an approved drug (FDA (2017))
Comment: Abaloparatide is a synthetic analogue of the 34 amino-terminal residues of human parathyroid hormone-related protein (PTHrP) [1]. Compare this to the approved drug teriparatide which is a synthetic analogue of human parathyroid hormone (PTH). Abaloparatide and teriparatide are synthetic peptides that help grow and strengthen bone.
1. Augustine M, Horwitz MJ. (2013)
Parathyroid hormone and parathyroid hormone-related protein analogs as therapies for osteoporosis.
Curr Osteoporos Rep, 11 (4): 400-6. [PMID:24078470]
2. Miller PD, Hattersley G, Riis BJ, Williams GC, Lau E, Russo LA, Alexandersen P, Zerbini CA, Hu MY, Harris AG et al.. (2016)
Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial.
JAMA, 316 (7): 722-733. [PMID:27533157]