Ligand id: 8314

Name: esuberaprost

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 86.99
Molecular weight 398.21
XLogP 2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
The binding affinity (Kd) of beraprost for a single binding site on human platelets is reported in [2] as 133nM, with the affinity of the active enantiomer APS-314d (= esuberaprost) being 100-fold higher, i.e. approximately 13nM.
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IP receptor Hs Agonist Agonist 7.9 pKd - 2
pKd 7.9 (Kd 1.3x10-8 M) [2]