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Synonyms: APS-314D free acid | BPS-314d
Compound class: Synthetic organic
Comment: Esuberaprost is a defined enantiomer of the racemate beraprost and represents the active enantiomer . Like beraprost, the compound is a prostacyclin IP1 receptor agonist.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Demolis JL, Robert A, Mouren M, Funck-Brentano C, Jaillon P. (1993)
Pharmacokinetics and platelet antiaggregating effects of beraprost, an oral stable prostacyclin analogue, in healthy volunteers.
J Cardiovasc Pharmacol, 22 (5): 711-6. [PMID:7506323]
2. Kajikawa N, Nogimori K, Murata T, Nishio S, Uchiyama S. (1989)
Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets.
Arzneimittelforschung, 39 (4): 495-9. [PMID:2665758]