compound A [PMID 24997608]

Ligand id: 8418

Name: compound A [PMID 24997608]

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 49.77
Molecular weight 405.13
XLogP 6.69
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
CpdA acts as a potent anti-inflammatory agent in vitro and in vivo, and improves glucose tolerance (and other diabetes related parameters) in a mouse model of type 2 diabetes [1].
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
FFA4 receptor Hs Agonist Agonist 7.6 pEC50 - 1
pEC50 7.6 [1]
Description: Fluorometric calcium assay using FLIPR methodology.