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Compound class: Synthetic organic
Comment: Compound A is a selective agonist of the free fatty acid receptor 4 (FFA4R) . The compound is a small molecule, orally active mimic of ω-3-fatty acids, the endogenous ligands of FFA4R .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Oh da Y, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM et al.. (2014)
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Nat Med, 20 (8): 942-7. [PMID:24997608]
2. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM. (2010)
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
Cell, 142 (5): 687-98. [PMID:20813258]