peptide KLK2b(c1)   Click here for help

GtoPdb Ligand ID: 8484

Compound class: Peptide or derivative
Comment: Peptide KLK2b(c1) is a selective inhibitor of glandular kallikrein (KLK2) [4], a testis-specific serine protease. KLK2 inhibitors are being investigated as novel therapeutics to prevent the metastasis of prostate cancer [1-3,5-7].
Bioactivity Comments
Peptide KLK2b(c1) inhibits the protease activity of human glandular kallikrein (KLK2) by 97% [4].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kallikrein related peptidase 2 Primary target of this compound Hs Inhibitor Inhibition - - - 4
⤷ [4]