HIV-1 matrix protein p17   Click here for help

GtoPdb Ligand ID: 8495

Comment: The p17 protein resides at the amino terminal ends of both the p55gag and p160gag-pol HIV proteins, and is essential for targeting these proteins to the plasma membrane to facilitate the assembly and budding of viral particles. p17 has been reported to bind to the CXCR1 chemokine receptor [1], inducing an IL-8-like cytokine response in monocytes.
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCR2 Hs Agonist Agonist 6.9 pKd - 1
pKd 6.9 (Kd 1.3x10-7 M) [1]