HIV-1 matrix protein p17   Click here for help

GtoPdb Ligand ID: 8495

Comment: The p17 protein resides at the amino terminal ends of both the p55gag and p160gag-pol HIV proteins, and is essential for targeting these proteins to the plasma membrane to facilitate the assembly and budding of viral particles. p17 has been reported to bind to the CXCR1 chemokine receptor [1], inducing an IL-8-like cytokine response in monocytes.
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1. Giagulli C, Magiera AK, Bugatti A, Caccuri F, Marsico S, Rusnati M, Vermi W, Fiorentini S, Caruso A. (2012)
HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation.
Blood, 119 (10): 2274-83. [PMID:22262769]