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Synonyms: REGN475 | SAR164877
Compound class: Antibody
Comment: Fasinumab is an investigational, fully human IgG4κ monoclonal antibody targeting nerve growth factor (NGF).
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record.
BLAST peptide sequence analysis reveals identical matches to peptide sequences submitted with patent US7988967 , with the preferred antibody being called REGN475 therein. REGN475 exhibits high specificity for human NGF, does not cross-react with closely related neurotrophin-3 (NT-3) and inhibits binding of NGF to its receptors TrkA (NTRK1) and p75 (NGFR) .
|Fasinumab (REGN475) blocks NGF binding to its receptors TrkA and p75 with IC50 values of 20 and 22 pM respectively, and inhibits NGF-mediated TrkA/p75 signalling in PC12 cells with IC50 of 9.6pM . A proof-of-concept study reported that fasinumab provided no clinical benefit in patients with acute sciatic pain .|
|Selectivity at ligand targets|
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