PIK-108

Ligand id: 8968

Name: PIK-108

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 54.71
Molecular weight 364.18
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Note that some bioactivity data may relate to the compound without specified stereochemistry [1], as represented by ChEMBL compound CHEMBL2064328.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Hs Allosteric modulator Negative 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.8x10-8 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Hs Allosteric modulator Negative 6.2 pIC50 - 1
pIC50 6.2 (IC50 6.58x10-7 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Hs Allosteric modulator Negative <5.0 pIC50 - 1
pIC50 <5.0 (IC50 >1x10-5 M) [1]