conessine

Ligand id: 8981

Name: conessine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 6.48
Molecular weight 356.32
XLogP 5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Conessine also has high affinity for human α2C-adrenoceptor (Ki 10.6nM) [3].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
H3 receptor Hs Antagonist Antagonist 8.3 pKi - 1
pKi 8.3 [1]
H1 receptor Hs Antagonist Antagonist <5.0 pKi - 1
pKi <5.0 (Ki >1x10-5 M) [1]
H2 receptor Hs Antagonist Antagonist <5.0 pKi - 1
pKi <5.0 (Ki >1x10-5 M) [1]
H4 receptor Hs Antagonist Antagonist <5.0 pKi - 1
pKi <5.0 (Ki >1x10-5 M) [1]