PD-140548

Ligand id: 904

Name: PD-140548

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 13
Topological polar surface area 120.52
Molecular weight 557.29
XLogP 5.45
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCK1 receptor Rn Antagonist Antagonist 8.6 pIC50 - 2
pIC50 8.6 (IC50 2.5x10-9 M) [2]
CCK2 receptor Rn Antagonist Antagonist 6.6 pIC50 - 1
pIC50 6.6 [1]