GtoPdb Ligand ID: 9047

Synonyms: BMS-936557 | MDX-1100
Compound class: Antibody
Comment: Eldelumab (BMS-936557 and formerly MDX-1100) is a a fully human monoclonal antibody targeting the chemokine CXCL10 (a.k.a. interferon-γ-inducible protein-10 or IP-10) [1]. It is being investigated for its anti-inflammatory action in autoimmune conditions.
BLAST peptide sequence analysis reveals exact matches with heavy and light chain variable regions claimed in patent US8258266, and identify eldelumab as clone 6A5 [1].
Bioactivity Comments
Eldelumab does not bind other identified CXCR3 ligands CXCL9 (a.k.a. MIG) and CXCL11 (a.k.a. ITAC) [1].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCL10 Hs Antibody Binding 9.1 pKd - 1
pKd 9.1 (Kd 7.2x10-10 M) [1]