eldelumab   Click here for help

GtoPdb Ligand ID: 9047

Synonyms: BMS-936557 | MDX-1100
Immunopharmacology Ligand
Compound class: Antibody
Comment: Eldelumab (BMS-936557 and formerly MDX-1100) is a a fully human monoclonal antibody targeting the chemokine CXCL10 (a.k.a. interferon-γ-inducible protein-10 or IP-10) [1]. It is being investigated for its anti-inflammatory action in autoimmune conditions.
BLAST peptide sequence analysis reveals exact matches with heavy and light chain variable regions claimed in patent US8258266, and identify eldelumab as clone 6A5 [1].
Bioactivity Comments
Eldelumab does not bind other identified CXCR3 ligands CXCL9 (a.k.a. MIG) and CXCL11 (a.k.a. ITAC) [1].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCL10 Primary target of this compound Hs Antibody Binding 9.1 pKd - 1
pKd 9.1 (Kd 7.2x10-10 M) [1]