|
Synonyms: BMS-936557 | MDX-1100
Compound class:
Antibody
Comment: Eldelumab (BMS-936557 and formerly MDX-1100) is a a fully human monoclonal antibody targeting the chemokine CXCL10 (a.k.a. interferon-γ-inducible protein-10 or IP-10) [1]. It is being investigated for its anti-inflammatory action in autoimmune conditions.
BLAST peptide sequence analysis reveals exact matches with heavy and light chain variable regions claimed in patent US8258266, and identify eldelumab as clone 6A5 [1]. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Rheumatoid arthritis |
Disease Ontology:
DOID:7148 OMIM: 180300 |
No progress beyond Phase 2 trial. | |
| Ulcerative colitis |
Disease Ontology:
DOID:8577 OMIM: 266600 Orphanet: ORPHA771 |
No progress beyond Phase 2 trial. | |
