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Synonyms: compound 15e [PMID: 9544210]  | TBC 1269 | TBC-1269 | TBC1269
Compound class: Synthetic organic
Comment: Bimosiamose is a synthetic pan-selectin antagonist  being investigated as a novel anti-inflammatory agent, primarily for controlling allergic respiratory diseases [7,9], but it has also been reported to provide benefit in ischemia/reperfusion injury [1-2,5-6,8]. The primary role of selectin inhibitors appears to be disruption of early events in the migration process (possibly mediated through E-selectin ), thereby inhibiting their eventual extravasation from blood to the inflammed tissue.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|We do not include the selectins as molecular targets in this database.
Bimosiamose (TBC1269) has a reported IC50 of 70μM in a P-selectin HL-60 cell assay .
|Selectivity at other protein targets|
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