Dendroaspis natriuretic peptide   Click here for help

GtoPdb Ligand ID: 9070

Abbreviated name: DNP
Comment: Dendroaspis natriuretic peptide, a snake venom ligand, shares structural similarity to the other known natriuretic peptides, atrial, brain, and C-type natriuretic peptides, in that they all have a 17 amino acid ring structure created by a single disulphide bond [1]. It is natriuretic and diuretic and is a potent activator of cGMP. It causes vasodilation, with beneficial cardiovascular and renal properties in vivo [2].
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Bioactivity Comments
Activates natriuretic peptide receptor A (NPR-A), but is a poor agonist of NPR-B [3]. Not degraded by neutral endopeptidase (NEP, neprilysin).
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Guanylyl cyclase-A Hs Agonist Agonist 9.7 pKd - 3
pKd 9.7 (Kd 2x10-10 M) [3]
Description: Binding affinity for the iodinated peptide.