Dendroaspis natriuretic peptide   Click here for help

GtoPdb Ligand ID: 9070

Abbreviated name: DNP
Comment: Dendroaspis natriuretic peptide, a snake venom ligand, shares structural similarity to the other known natriuretic peptides, atrial, brain, and C-type natriuretic peptides, in that they all have a 17 amino acid ring structure created by a single disulphide bond [1]. It is natriuretic and diuretic and is a potent activator of cGMP. It causes vasodilation, with beneficial cardiovascular and renal properties in vivo [2].
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1. Lisy O, Jougasaki M, Heublein DM, Schirger JA, Chen HH, Wennberg PW, Burnett JC. (1999)
Renal actions of synthetic dendroaspis natriuretic peptide.
Kidney Int, 56 (2): 502-8. [PMID:10432389]
2. Lisy O, Lainchbury JG, Leskinen H, Burnett Jr JC. (2001)
Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure.
Hypertension, 37 (4): 1089-94. [PMID:11304508]
3. Singh G, Kuc RE, Maguire JJ, Fidock M, Davenport AP. (2006)
Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure.
Circ Res, 99 (2): 183-90. [PMID:16778132]