carotuximab   Click here for help

GtoPdb Ligand ID: 9098

Synonyms: c-SN6j | TRC-105 | TRC105
Compound class: Antibody
Comment: Carotuximab is an investigational, chimeric mouse/human anti-endoglin monoclonal antibody, with potential immunomodulatory and antineoplastic action.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Protein BLAST analysis reveals 100% matches with peptides claimed in patent US8221753, and to the antibody designated TR105 (c-SN6j) therein [1].
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Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
endoglin (CD105) Primary target of this compound Hs Antibody Binding >9.0 pKd - 1
pKd >9.0 (Kd <1x10-9 M) [1]