Synonyms: derivative 11a [PMID: 27115835]
Compound class:
Synthetic organic
Comment: eCF506 is a potent and selective inhibitor of SRC family kinases, with activity against breast cancer cells in vitro and in vivo. Design and discovery of this compound is reported in [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
eCF506 is >950-fold selective for SRC kinases over ABL kinase [1]. IC50s for inhibition of the receptor tyrosine kinases KIT, mTOR, PDGFRα and RET are all >1000 nM [1]. |
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