probe 1.1 [PMID: 24187130]   Click here for help

GtoPdb Ligand ID: 9191

Synonyms: KSC-12-192
Compound class: Synthetic organic
Comment: Probe 1.1 is a biased agonist for the κ opioid receptor [1]. The compound was designed to preferentially bias KOR activation towards G protein signaling with minimal effects on βarrestin2 recruitment and downstream ERK1/2 activation.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 82.04
Molecular weight 430.11
XLogP 6.11
No. Lipinski's rules broken 1
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Canonical SMILES Cc1ccc(cc1C(F)(F)F)CSc1nnc(n1Cc1ccco1)c1ccccn1
Isomeric SMILES Cc1ccc(cc1C(F)(F)F)CSc1nnc(n1Cc1ccco1)c1ccccn1
InChI InChI=1S/C21H17F3N4OS/c1-14-7-8-15(11-17(14)21(22,23)24)13-30-20-27-26-19(18-6-2-3-9-25-18)28(20)12-16-5-4-10-29-16/h2-11H,12-13H2,1H3
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
κ receptor Hs Agonist Agonist 9.6 pKi - 1
pKi 9.6 (Ki 2.5x10-10 M) [1]
κ receptor Hs Agonist Biased agonist 5.4 – 7.5 pEC50 - 1
pEC50 7.5 (EC50 3.1x10-8 M) [1]
Description: Measuring [35S]GTPγS binding
pEC50 5.4 (EC50 4.129x10-6 M) [1]
Description: Measuring βarrestin2 recruitment