Ligand id: 9281

Name: fezakinumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Fezakinumab shows cross-species reactivity, blocking IL-22 receptor activation and cellular proliferation induced by murine, monkey and rat IL-22 in addition to the human cytokine [1].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-22 Hs Antibody Binding 10.3 pKd - 1
pKd 10.3 (Kd 5.4x10-11 M) [1]
Description: Binding in an ELISA using immobilized human IL-22