fezakinumab   Click here for help

GtoPdb Ligand ID: 9281

Synonyms: ILV-094
Immunopharmacology Ligand
Compound class: Antibody
Comment: Fezakinumab is a fully human monoclonal anti-IL22 antibody being investigated for clinical antiinflammatory utility against acute and chronic conditions.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequences identical to those of the heavy and light variable regions of fezakinumab are claimed in patent US7811567, leading to identification of clone 356A11 as fezakinumab [1].
Immunopharmacology Disease
Disease X-Refs Comment References
Psoriasis Disease Ontology: DOID:8893
Completed Phase 1 trial for psoriasis (see NCT00563524).
Atopic dermatitis Disease Ontology: DOID:3310
OMIM: 603165
Active Phase 2 study NCT01941537.
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Completed Phase 2 trial for RA (see NCT00883896).