Ligand id: 9293

Name: brazikumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
It is unclear which anti-IL-23 antibody in patent WO2011056600 is AMG 139, although antibodies B and E were crystalised to produce X-ray structures, suggesting these were preferred agents [3]. In binding affinity experiments using recombinant human IL-23, all of the chosen antibodies produced equilibrium dissociation constant (KD) values <4pM [3].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-23A Hs Antibody Binding >11.4 pKd - 3
pKd >11.4 (Kd <4x10-12 M) [3]
Description: Measured using KinExA technology (a kinetic exclusion assay)