Bioactivity Comments

It is unclear which anti-IL-23 antibody in patent WO2011056600 is AMG 139, although antibodies B and E were crystalised to produce X-ray structures, suggesting these were preferred agents [3]. In binding affinity experiments using recombinant human IL-23, all of the chosen antibodies produced equilibrium dissociation constant (KD) values <4pM [3].

Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference IL-23A Hs Antibody Binding >11.4 pKd - 3 ⤷ pKd >11.4 (Kd <4x10-12 M) [3] Description: Measured using KinExA technology (a kinetic exclusion assay)