View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species
|At 10 μM, AR-13324 inhibits NET by 96% and SERT by 94% . In a kinase screening panel 0.5 μM AR-13324 inhibited 11 kinases by >90%. Of these 11, ROCK1, ROCK2, PKCδ and PKCη are the only four identified as potential targets for lowering intra-ocular pressure. The S-enantiomer is the more active isomer, with the R-enantiomer having a lower Ki of 106nM and the racemate having a Ki of 4.2nM vs. ROCK2 . Preclinical evaluation is reported in .