raclopride

Ligand id: 94

Name: raclopride

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 61.8
Molecular weight 346.09
XLogP 3.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
D2 receptor Rn Antagonist Antagonist 7.7 – 9.3 pKi - 3-4
pKi 7.7 – 9.3 [3-4]
D2 receptor Hs Antagonist Antagonist 8.0 pKi - 1
pKi 8.0 (Ki 1x10-8 M) [1]
D3 receptor Hs Antagonist Antagonist 7.9 pKi - 1
pKi 7.9 [1]
D3 receptor Rn Antagonist Antagonist 7.5 pKi - 4
pKi 7.5 [4]
D4 receptor Rn Antagonist Antagonist 5.7 pKi - 3
pKi 5.7 [3]
5-HT1A receptor Hs Antagonist Antagonist 5.2 pKi - 2
pKi 5.2 [2]