Ligand id: 9460

Name: AC264613

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 70.56
Molecular weight 399.06
XLogP 4.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
AC264613 exhibits no activity at the PAR1, PAR3 or PAR4 receptors [2]. In vivo, AC264613 causes persistent and dose-dependent (pro-inflammatory) activity in paw edema and thermal hyperalgesia assays [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
PAR2 Hs Agonist Agonist 7.5 pEC50 - 2
pEC50 7.5 (EC50 3.16x10-8 M) [2]