Ligand id: 9644

Name: DSM265

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.11
Molecular weight 415.07
XLogP 4.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
The antiparasite activitity of DSM265 has been evaluated in vitro for all Plasmodium lifecycle stages [4]. Asexual blood stage activity was examined using a panel of culture-adapted P. falciparum strains, with no evidence of reduced potency against drug resistant strains (EC501-4nM). DSM265 is inactive against the sexual blood stage and in the mosquito stage.
Whole organism assay data
Key to terms and symbols Click on species/strain names for details Click column headers to sort
MOA/likely target Sp. Assay description Type Action Value Parameter Concentration range (M) Reference
Plasmodium falciparum dihydroorotate dehydrogenase PfNF54 Parasite growth inhibition assay - - 7.5 pIC50 - 4
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [4]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)