Ligand id: 9644

Name: DSM265

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.11
Molecular weight 415.07
XLogP 4.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
DSM265 is active against both asexual blood and liver stages of P. falciparum [4].
Favorable pharmacokinetic properties, compatible with single-dose treatment, have facilitated progression to clinical trial [2,5].

Potential Target/Mechanism Of Action: DSM265 is a selective inhibitor of malarial dihydroorotate dehydrogenase (DHODH) in vitro.
Target Candidate Profiles
Profile Intended Use Target Stage Comment References
TCP-1 reduce parasite burden asexual blood stages
TCP-4 chemoprotection hepatic schizonts