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Molecular properties generated using the CDK
|Guide to Malaria Pharmacology Comments|
|DSM265 is active against both asexual blood and liver stages of P. falciparum .
Favorable pharmacokinetic properties, compatible with single-dose treatment, have facilitated progression to clinical trial [2,5].
Potential Target/Mechanism Of Action: DSM265 is a selective inhibitor of malarial dihydroorotate dehydrogenase (DHODH) in vitro.
|Target Candidate Profiles|
|Profile||Intended Use||Target Stage||Comment||References|
|TCP-1||reduce parasite burden||asexual blood stages|