Ligand id: 9661

Name: GSK2981278

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 84.45
Molecular weight 461.22
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
GSK2981278 inhibits activation of the IL17 promoter in a reporter gene assay [2]. Concentrations of GSK2981278 ≥ 3nM leads to almost complete inhibition of IL-17A protein secretion.
Selectivity at nuclear hormone receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
RAR-related orphan receptor-γ Hs Agonist Inverse agonist 8.5 pIC50 - 2
pIC50 8.5 (IC50 3.2x10-9 M) [2]
Description: Measuring inhibition of human T cell cytokine production under Th17 skewing conditions.