MAB92   Click here for help

GtoPdb Ligand ID: 9665

Immunopharmacology Ligand
Compound class: Antibody
Comment: MAB92 is an IL-36 receptor antagonistic antibody that mimics the action of IL-36RA cytokine [1]. It is selective for the human IL-36 receptor. A related construct with overlapping epitope binding and function, MAB04, is mouse cross-reactive and is suitable for in vivo pharmacology studies [1].
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Bioactivity Comments
MAB92 blocks pro-inflammatory IL-36-induced actions such as NFκB activation and IL-8 production in primary human dermal fibroblasts and human keratinocytes in vitro [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-1 receptor-like 2 Primary target of this compound Hs Antibody Antagonist 10.6 pKd - 1
pKd 10.6 (Kd 2.4x10-11 M) [1]