sutimlimab   Click here for help

GtoPdb Ligand ID: 9807

Synonyms: BIVV009 | IPN-009 | IPN009 | TNT009
Immunopharmacology Ligand
Compound class: Antibody
Comment: Sutimlimab (TNT009) is a humanised, monoclonal antibody that is designed to selectively inhibit the classical complement pathway by targeting C1s [3]; C1s being the serine protease component of the C1-complex in the complement pathway of the immune system. Sutimlimab is claimed in True North Therapeutics' patent WO2016164358A1 [4] and is likely to be the antibody designated as VH4/VK2 based on peptides matches between those provided in the submission to the WHO for INN sutimlimab and those in the patent application (namely SEQ IDs NOs 42 and 44). The research code TNT009 was changed to BIVV009 when True North Therapeutics were acquired by Bioverativ (a Sanofi company) in 2017, and clinical trials are ongoing using both of these code names.
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Bioactivity Comments
Preclinical details of TNT009 in vitro activity are published in [5], and results from the first-in-human Phase 1 trial are reported in [2]. In kidney transplant patients, TNT009 (BIVV009) effectively blocks alloantibody-triggered complement pathway activation, but this fails to translate to therapeutic benefit in the short term [1]. Further studies are needed to fully evaluate the therapeutic value of complement pathway blockade in transplant patients.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C1s Primary target of this compound Hs Antibody Binding 9.6 pKd - 4
pKd 9.6 (Kd 2.6x10-10 M) [4]