Ligand id: 9925

Name: balamapimod

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 107.54
Molecular weight 573.21
XLogP 5.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Raf-1 proto-oncogene, serine/threonine kinase Hs Inhibitor Inhibition 6.9 pIC50 - 1
pIC50 6.9 (IC50 1.14x10-7 M) [1]
Description: Measuring c-Raf mediated activation of MEK and phosphorylation of MEK substrate.
SRC proto-oncogene, non-receptor tyrosine kinase Hs Inhibitor Inhibition 6.6 pIC50 - 1
pIC50 6.6 (IC50 2.81x10-7 M) [1]
Description: Measuring inhibition substrate phosphorylation by p60c-src tyrosine kinase in an ELISA, using an anti-phosphotyrosine detection antibody.