Ligand id: 1016

Name: tamoxifen

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 12.47
Molecular weight 371.22
XLogP 7.14
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used for the treatment of metastatic breast cancer and ductal carcinoma.
Mechanism Of Action and Pharmacodynamic Effects
Binds to estrogen receptors inducing a conformational change resulting in either blockage or change in expression of estrogen-dependent genes. Prolonged binding of the drug to the nuclear chromatin results in reduced DNA polymerase activity impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response.
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