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zotepine is an approved drug
Compound class: Synthetic organic
Comment: Zotepine is an atypical antipsychotic drug, with antagonist activity at dopamine and serotonin receptors.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Used to treat schizophrenia.
This drug is not approved for use in the UK or the US. Other national approval agencies may have granted marketing authorisation. The FDA website lists Japan, Taiwan, Indonesia, South Korea, Bulgaria, Czech Republic, Lithuania, Portugal and Germany as international markets for zotepine.
|Mechanism Of Action and Pharmacodynamic Effects|
|Zopetine is a dual function antagonist of dopamine and serotonin receptors. Reducing the activity of these receptors effects improvement of psychotic symptoms and mania.|