zotepine   Click here for help

GtoPdb Ligand ID: 103

Synonyms: Zoleptil®
Approved drug PDB Ligand
zotepine is an approved drug
Compound class: Synthetic organic
Comment: Zotepine is an atypical antipsychotic drug, with antagonist activity at dopamine and serotonin receptors.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 37.77
Molecular weight 331.08
XLogP 5.12
No. Lipinski's rules broken 1
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Canonical SMILES CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C
Isomeric SMILES CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C
InChI InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
No information available.
Summary of Clinical Use Click here for help
Used to treat schizophrenia.
This drug is not approved for use in the UK or the US. Other national approval agencies may have granted marketing authorisation. The FDA website lists Japan, Taiwan, Indonesia, South Korea, Bulgaria, Czech Republic, Lithuania, Portugal and Germany as international markets for zotepine.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Zopetine is a dual function antagonist of dopamine and serotonin receptors. Reducing the activity of these receptors effects improvement of psychotic symptoms and mania.