opipramol   Click here for help

GtoPdb Ligand ID: 11247

Synonyms: Insidon®
Approved drug
opipramol is an approved drug
Compound class: Synthetic organic
Comment: Opipramol is an atypical tricyclic antidepressant (TCA) [3]. It acts primarily as a sigma (σ) receptor agonist. Weak antiviral activity of opipramol dihydrochloride against SARS-CoV-2 (in Vero E6 cells; EC50 5 μM) was reported by Touret et al. [4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 29.95
Molecular weight 363.23
XLogP 3.25
No. Lipinski's rules broken 0
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Canonical SMILES OCCN1CCN(CC1)CCCN1c2ccccc2C=Cc2c1cccc2
Isomeric SMILES OCCN1CCN(CC1)CCCN1c2ccccc2C=Cc2c1cccc2
InChI InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2
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Summary of Clinical Use Click here for help
Opipramol is used for its antidepressant and anxiolytic activities [1]. It is not apporved by the EMA or FDA, but has marketing authorisations in countries including Germany, Turkey, Kuwait, Switzerland, Austria and Poland.