opipramol   Click here for help

GtoPdb Ligand ID: 11247

Synonyms: Insidon®
Approved drug
opipramol is an approved drug
Compound class: Synthetic organic
Comment: Opipramol is an atypical tricyclic antidepressant (TCA) [3]. It acts primarily as a sigma (σ) receptor agonist. Weak antiviral activity of opipramol dihydrochloride against SARS-CoV-2 (in Vero E6 cells; EC50 5 μM) was reported by Touret et al. [4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 29.95
Molecular weight 363.23
XLogP 3.25
No. Lipinski's rules broken 0
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Canonical SMILES OCCN1CCN(CC1)CCCN1c2ccccc2C=Cc2c1cccc2
Isomeric SMILES OCCN1CCN(CC1)CCCN1c2ccccc2C=Cc2c1cccc2
InChI InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
1838 opipramol
Synonyms Click here for help
Database Links Click here for help
BindingDB Ligand 50170636
CAS Registry No. 315-72-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL370753
DrugBank Ligand DB12930
DrugCentral Ligand 1993
GtoPdb PubChem SID 434122307
PubChem CID 9417
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