Synonyms: A-157378-0 | A-1573780 | ABT-378 | ABT378 | Aluviran® | Kaletra® (LPV+RTV)
lopinavir is an approved drug (FDA (2000), EMA (2001))
Compound class:
Synthetic organic
Comment: Lopinavir is an antiretroviral protease inhibitor. It has subsequently been discovered to exhibit antiviral activity against human papilloma virus (HPV), and to inhibit MERS-CoV replication in vitro [3]. Antiviral activity against SARS-CoV-2 has been explored [1], however lopinavir/ritonavir therapy provided no benefit in hospitalised COVID-19 patients [2].
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No information available. |
Summary of Clinical Use ![]() |
Lopinavir is used in combination with ritonavir to treat and prevent human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). |