Synonyms: A-157378-0 | A-1573780 | ABT-378 | ABT378 | Aluviran® | Kaletra® (LPV+RTV)
lopinavir is an approved drug (FDA (2000), EMA (2001))
Compound class:
Synthetic organic
Comment: Lopinavir is an antiretroviral protease inhibitor. It has subsequently been discovered to exhibit antiviral activity against human papilloma virus (HPV), and to inhibit MERS-CoV replication in vitro [3]. Antiviral activity against SARS-CoV-2 has been explored [1], however lopinavir/ritonavir therapy provided no benefit in hospitalised COVID-19 patients [2].
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References |
1. Böhm R, Bulin C, Waetzig V, Cascorbi I, Klein HJ, Herdegen T. (2021)
Pharmacovigilance-based drug repurposing: The search for inverse signals via OpenVigil identifies putative drugs against viral respiratory infections. Br J Clin Pharmacol, 87 (11): 4421-4431. [PMID:33871897] |
2. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M et al.. (2020)
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med, 382 (19): 1787-1799. [PMID:32187464] |
3. de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ. (2014)
Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. Antimicrob Agents Chemother, 58 (8): 4875-84. [PMID:24841269] |
4. Sham HL, Betebenner DA, Herrin T, Kumar G, Saldivar A, Vasavanonda S, Molla A, Kempf DJ, Plattner JJ, Norbeck DW. (2001)
Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett, 11 (11): 1351-3. [PMID:11378352] |