anagliptin   Click here for help

GtoPdb Ligand ID: 11582

Synonyms: compound 4a [PMID: 22019046] | CWP-403 | SK-0403 | SK0403 | Suiny®
Approved drug PDB Ligand
anagliptin is an approved drug (Japan (2012))
Compound class: Synthetic organic
Comment: Anagliptin (SkK-0403) is a dipeptidyl peptidase-4 (DPP4) inhibitor [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 115.42
Molecular weight 383.21
XLogP 0.03
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES N#C[C@@H]1CCCN1C(=O)CNC(CNC(=O)c1cnc2n(c1)nc(c2)C)(C)C
Isomeric SMILES N#C[C@@H]1CCCN1C(=O)CNC(CNC(=O)c1cnc2n(c1)nc(c2)C)(C)C
InChI InChI=1S/C19H25N7O2/c1-13-7-16-21-9-14(11-26(16)24-13)18(28)22-12-19(2,3)23-10-17(27)25-6-4-5-15(25)8-20/h7,9,11,15,23H,4-6,10,12H2,1-3H3,(H,22,28)/t15-/m0/s1
InChI Key LDXYBEHACFJIEL-HNNXBMFYSA-N
No information available.
Summary of Clinical Use Click here for help
Anagliptin is approved in Japan and is used in the treatment of type 2 diabetes [2].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT00532506 Phase II Dose-Finding Study of SK-0403 With Type 2 Diabetes Mellitus Phase 2 Interventional Sanwa Kagaku Kenkyusho Co., Ltd.
NCT01169090 A Study Comparing the Safety, Tolerance, and Efficacy of Various Doses of SK-0403 Versus Placebo and Sitagliptin 100 mg in Patients Not Well-Controlled on Metformin Therapy Phase 2 Interventional Kowa Research Institute, Inc.
NCT01131091 A Multicenter, Open Label, Single Dose Study to Evaluate the Effect of Renal Insufficiency on the Pharmacokinetics of SK 0403 Phase 1 Interventional Kowa Research Institute, Inc.
NCT01529541 Efficacy and Safety of CWP-0403 Compared to Sitagliptin in Patients With Type 2 Diabetes Mellitus Insufficiently Controlled With Metformin Alone Phase 3 Interventional JW Pharmaceutical
NCT01529528 A Study to Efficacy and Safety of CWP-0403 in Type 2 Diabetes Mellitus Patients Phase 3 Interventional JW Pharmaceutical